Cells make exosomes. Esphera SynBio modifies cells such that they make modified exosomes.

These modified exosomes can be designed to have targeting moieties on their surface and a variety of protein or RNA payloads in their lumen.

Cells can be modified to do so in vitro (i.e. in a bioreactor) or in vivo (i.e. following delivery of our transgenes by any vector)

our technology

These multimeric proteins can include extravesicular targeting domains, luminal proteins (antigens, enzymes, adaptors etc) facilitating the packaging of various RNA species (siRNA, mRNA, saRNA).

This allows for the production of, for example, therapeutic exosomes in vivo.

Esphera’s lead application of this platform technology is the modification of tumour cells in vivo such that typically protumourigenic and immunosuppressive tumour-derived exosomes become immunostimulatory, antigen-bearing modifiers of the TME and bespoke, patient specific cancer vaccines.